Medicinal Redox Inorganic Chemistry

Increased challenges in health care (ageing populations, chronic disease, spiralling costs, etc.) urgently call for the development and exploitation of less conventional, non-carbon-based bioactive molecules that meet the biomedical requirements of the time ahead of us.

Since reactive oxygen and nitrogen species (ROS and RNS), as well as sulfur containing low-molecular weight species play major roles in the pathogenesis of inflammation and nociception, we propose the development of redox-active metal complexes and small sulfur containing species that are capable to inactivate or modify ROS/RNS for the patient benefit: (a) as pharmacological tools for analyzing the function of ROS/RNS in (patho)physiological processes and (b) as new low-cost inorganic candidates for the treatment of chronic inflammatory diseases in an ageing population. Inorganic chemists, biochemists, and physical chemists, as well as medical/clinical experts of FAU are working together (coordinated by the Chair of Bioinorganic Chemistry) within this unique interdisciplinary research platform.

• Manganese, Iron and Zinc based enzyme mimetics

• Bioinorganic Chemistry of H2S, Nitrogen species and their crosstalk

• Chemistry of Oxidative Stress

 

Key Publications

• J. Inorg. Biochem., 2024, 252, 112478.
• Angew. Chem., Int. Ed. 2019, 58(24), 7997–8001.
• Nat. Chem. 2018, 10(12), 1207–1212.
• Inorg. Chem. 2017, 56(11), 6076–6093.
• Inorg. Chem. 2015, 54(19), 9367–9380.
• J. Am. Chem. Soc. 2015, 137(20), 6602–6615.
• Nat. Commun. 2014, 5, 4381.
• Angew. Chem. Int. Ed. 2013, 52(46), 12061–12064.
• J. Med. Chem. 2013, 56(4), 1499–1508.
• Antiox. Redox Signal. 2013, 18(2), 170–178.
• J. Am. Chem. Soc. 2012, 134(29), 12016–12027.
• J. Inorg. Biochem. 2012, 109, 26–32.
• Angew. Chem. Int. Ed. 2010, 49(25), 4228–4232.